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39. 39. M. Ferguson et al. (2008), "Effect of genomic variation in the challenge virus on the neutralization titres of recipients of inactivated JE vaccines--report of a collaborative study on PRNT50 assays for Japanese encephalitis virus (JE) antibodies", Biologicals. 36(2), pg. 111-6.
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43. Hội đồng Dược điển Việt Nam (2017), Dược điển Việt Nam V: Vắc xin Viêm não Nhật Bản, Bộ Y tế, Hà Nội.
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PHỤ LỤC
Phụ lục 1. SO SÁNH TRÌNH TỰ NUCLEOTIDE CỦA 03 CHỦNG (CHỦNG GIỐNG GỐC BV-MSV-021, BV-WSV- 031 VÀ CHỦNG THAM CHIẾU Beijing-Kanonji)
....|....|....|....| ....|....|....|....| ....|....|
10 20 30 40 50
BV-MSV-021 TTCAACTGTC TGGGAATGGG CAATCGTGAC TTCATAGAAG GAGCCAGTGG
BV-WSV-031 TTCAACTGTC TGGGAATGGG CAATCGTGAC TTCATAGAAG GAGCCAGTGG
Beijing-Ka TTCAACTGTC TGGGAATGGG CAATCGTGAC TTCATAGAAG GAGCCAGTGG
....|....|....|....| ....|....|....|....| ....|....|
60 70 80 90 100
BV-MSV-021 AGCCACTTGG GTGGACTTGG TGCTAGAAGG AGACAGCTGC TTGACAATCA
BV-WSV-031 AGCCACTTGG GTGGACTTGG TGCTAGAAGG AGACAGCTGC TTGACAATCA
Beijing-Ka AGCCACTTGG GTGGACTTGG TGCTAGAAGG AGACAGCTGC TTGACAATCA
....|....|....|....| ....|....|....|....| ....|....|
110 120 130 140 150
BV-MSV-021 TGGCAAACGA CAAACCAACA TTGGACGTCC GCATGATCAA CATCGAAGCT
BV-WSV-031 TGGCAAACGA CAAACCAACA TTGGACGTCC GCATGATCAA CATCGAAGCT
Beijing-Ka TGGCAAACGA CAAACCAACA TTGGACGTCC GCATGATCAA CATCGAAGCT
....|....|....|....| ....|....|....|....| ....|....|
160 170 180 190 200
BV-MSV-021 AGCCAACTTG CTGAGGTCAG AAGTTACTGC TATCATGCTT CAGTCACTGA
BV-WSV-031 AGCCAACTTG CTGAGGTCAG AAGTTACTGC TATCATGCTT CAGTCACTGA
Beijing-Ka AGCCAACTTG CTGAGGTCAG AAGTTACTGC TATCATGCTT CAGTCACTGA
....|....|....|....| ....|....|....|....| ....|....|
210 220 230 240 250
BV-MSV-021 CATCTCGACG GTGGCTCGGT GCCCCACGAC TGGAGAAGCC CACAACGAGA
BV-WSV-031 CATCTCGACG GTGGCTCGGT GCCCCACGAC TGGAGAAGCC CACAACGAGA
Beijing-Ka CATCTCGACG GTGGCTCGGT GCCCCACGAC TGGAGAAGCC CACAACGAGA
....|....|....|....| ....|....|....|....| ....|....|
260 270 280 290 300
BV-MSV-021 AGCGAGCTGA TAGTAGCTAT GTGTGCAAAC AAGGCTTCAC TGATCGTGGG
BV-WSV-031 AGCGAGCTGA TAGTAGCTAT GTGTGCAAAC AAGGCTTCAC TGATCGTGGG
Beijing-Ka AGCGAGCTGA TAGTAGCTAT GTGTGCAAAC AAGGCTTCAC TGATCGTGGG
310 320 330 340 350
BV-MSV-021 TGGGGCAACG GATGTGGACT TTTCGGGAAG GGAAGTATTG ACACATGTGC
BV-WSV-031 TGGGGCAACG GATGTGGACT TTTCGGGAAG GGAAGTATTG ACACATGTGC
Beijing-Ka TGGGGCAACG GATGTGGACT TTTCGGGAAG GGAAGTATTG ACACATGTGC
....|....|....|....| ....|....|....|....| ....|....|
360 370 380 390 400
BV-MSV-021 AAAATTCTCC TGCACCAGGA AAGCGATTGG GAGAACAATC CAGCCAGAAA
BV-WSV-031 AAAATTCTCC TGCACCAGGA AAGCGATTGG GAGAACAATC CAGCCAGAAA
Beijing-Ka AAAATTCTCC TGCACCAGGA AAGCGATTGG GAGAACAATC CAGCCAGAAA
....|....|....|....| ....|....|....|....| ....|....|
410 420 430 440 450
BV-MSV-021 ACATCAAATA CGAAGTTGGC ATTTTTGTGC ATGGAACCAC CACTTCGGAA
BV-WSV-031 ACATCAAATA CGAAGTTGGC ATTTTTGTGC ATGGAACCAC CACTTCGGAA
Beijing-Ka ACATCAAATA CGAAGTTGGC ATTTTTGTGC ATGGAACCAC CACTTCGGAA
....|....|....|....| ....|....|....|....| ....|....|
460 470 480 490 500
BV-MSV-021 AACCATGGGA ATTATTCAGC GCAAGTTGGG GCGTCCCAGG CGGCAAAGTT
BV-WSV-031 AACCATGGGA ATTATTCAGC GCAAGTTGGG GCGTCCCAGG CGGCAAAGTT
Beijing-Ka AACCATGGGA ATTATTCAGC GCAAGTTGGG GCGTCCCAGG CGGCAAAGTT
....|....|....|....| ....|....|....|....|....|....|
510 520 530 540 550
BV-MSV-021 TACAGTAACA CCTAATGCTC CTTCGATAAC CCTCAAACTT GGTGACTACG
BV-WSV-031 TACAGTAACA CCTAATGCTC CTTCGATAAC CCTCAAACTT GGTGACTACG
Beijing-Ka TACAGTAACA CCTAATGCTC CTTCGATAAC CCTCAAACTT GGTGACTACG
....|....| ....|....|....|....| ....|....| ....|....|
560 570 580 590 600
BV-MSV-021 GAGAAGTCAC ACTGGACTGT GAGCCAAGGA GTGGACTAAA CACTGAAGCG
BV-WSV-031 GAGAAGTCAC ACTGGACTGT GAGCCAAGGA GTGGACTAAA CACTGAAGCG
Beijing-Ka GAGAAGTCAC ACTGGACTGT GAGCCAAGGA GTGGACTAAA CACTGAAGCG
....|....| ....|....|....|....| ....|....|....|....|
610 620 630 640 650
BV-MSV-021 TTTTACGTCA TGACCGTGGG GTCAAAGTCA TTTTTGGTCC ATAGGGAATG
BV-WSV-031 TTTTACGTCA TGACCGTGGG GTCAAAGTCA TTTTTGGTCC ATAGGGAATG
Beijing-Ka TTTTACGTCA TGACCGTGGG GTCAAAGTCA TTTTTGGTCC ATAGGGAATG