7. Đào Đức Thiện, Lê Thị Hồng Nhung, Nguyễn Thanh Tâm, Trần Văn Sung, Tổng hợp một số dẫn xuất amide của 24-nor-3α,11α-dihydroxy-lup-20(29)- ene-28-oic acid chiết tách từ cây Ngũ gia bì hương, Tuyển tập báo cáo Hội nghị khoa học Viện Hóa học, 2011, 61-64.
THE NEW CONTRIBUTIONS OF THE THESIS
- This the first time species Pinus krempfii Lecomte has been studied on the chemical constituents and biological in Vietnam.
- Seven compounds named Tectochrysin (PK1), Pinostrobin (PK2), Pinobanksin (PK3), Galangin (PK4), Strobopinin (PK5), Cryptostrobin (PK6), Isolariciresinol (PK7) were isolated and elucidated from the root of Pinus krempfii Lecomte. Among these, two compounds PK4 and PK7 were isolated from this species for the first time.
- The isolated compounds has been studied on biological activities. The results showed that two compounds PK4 and PK7 have fairly good antioxidant activity (PK7: EC50 = 27,12 g/ml); four compounds: PK3, PK4, PK6 and PK7 exhibited cytotoxic activity on 4 human cancer cell lines including KB, HepG2, Lu MCF7.
- A new lupane-triterpene carboxylic acid named 11α,23-dihydroxy-3-oxo-lup- 20(29)-ene-28-oic acid (AT3), together with two known 24-nor-11α-hydroxy-3- oxo-lup-20(29)-ene-28-oic acid (AT1), 24-nor-3α,11α-dihydroxy-lup-20(29)-ene- 28-oic acid (AT2) with high content (0.26 and 0.25% of dried plant material, respectively) were isolated from the aerial part of Acanthopanax trifoliatus L.Merr.
- Starting from AT1 and AT2, 23 new derivatives, including: 4 ester (AT4-AT7), 1 oxo (AT8), 8 amide (AT9-AT17) derivatives of AT1 and 1 ester (AT18), 8 amide (AT19-AT26), 1 nitrile (AT27) derivatives of AT2 have been synthesized.
- Some of the synthesized compounds have been selected for the cytotoxicity test on 4 human cancer cell lines including KB, HepG2, MCF7 and Lu and antimicrobial assay to Bacillus subtilis for the first time. Among these, compounds AT11, AT12, AT13, AT22 showed stronger cytotoxicity than the parent compounds, especially compound AT22 are six to fifteen times more active than its lead compound on all four tested cell lines with IC50 values are 3,65 ÷ 4,42µg/ml. Three compounds AT11, AT16 and AT18 exhibited inhibitory activity against Bacillus subtilis with average level.
TÀI LIỆU THAM KHẢO
Có thể bạn quan tâm!
-
Nor-11 -O-Glutaryl-3-Oxo-Lup-20(29)-Ene-28-Oic Acid (At6): -
Hoạt Tính Sinh Học Của Các Hợp Chất Phân Lập Và Chuyển Hóa Hóa Học -
Thành Phần Hóa Học Của Loài Thông Lá Dẹt (Pinus Krempfii Lecomte) -
Nghiên cứu hóa học và thăm dò hoạt tính sinh học của loài thông lá dẹt (pinus krempfii lecomte) và ngũ gia bì hương (acanthopanax trifoliatus L. Merr) - 20 -
Nghiên cứu hóa học và thăm dò hoạt tính sinh học của loài thông lá dẹt (pinus krempfii lecomte) và ngũ gia bì hương (acanthopanax trifoliatus L. Merr) - 21
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