Lesson plan for developing students' capacity in Biology 12-14

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RANDOM MATE EXERCISES: (FREE MATE, MIXED MATE)

Lesson 1: Which of the following populations is in genetic equilibrium?

A. QTI : 0.32 AA : 0.64 Aa : 0.04 aa. BQT II: 0.04 AA: 0.64 Aa: 0.32 aa. C. QT III: 0.64 AA: 0.04 Aa: 0.32 aa. D. QT IV: 0.64 AA: 0.32 Aa: 0.04

aa

Solution: Use the formula p 2 AA xq 2 aa = ( 2pqAa / 2 ) 2

Consider QTI: 0.32 x 0.04 = ( 0.64 /2 ) 2 0.0128 is not equal to 0.1024

Consider QTII: 0.04 x 0.32 = ( 0.64 /2 ) 2 0.0128 is not equal to 0.1024

Consider QTIII: 0.64 x 0.32 = ( 0.04 /2 ) 2 0.2048 is not equal to 0.0004

Consider QTIV: 0.64 x 0.04 = ( 0.32 /2 ) 2 0.0256 = 0.0256 => Choose D

Lesson 2. A population consists of 120 individuals with genotype AA, 400 individuals with genotype Aa, and 680 individuals with genotype aa. The frequencies of alleles A and a in the above population are respectively:

A.0.265 and 0.735 B.0.27 and 0.73 C.0.25 and 0.75

D.0.3 and 0.7

Solution: Total number of individuals in the population: 120 + 400 + 680 = 1200

Genotype frequency AA = 120 / 1200 = 0.1 : Genotype frequency Aa = 400 / 1200 =

0.33

Genotype frequency aa = 680 / 1200 = 0.57

So: pA = 0.1 + 0.33 / 2 = 0.265; qa = 0.57 + 0.33 / 2 = 0.735 choose A

Lesson 3 : Gene BB determines red flowers, Bb determines pink flowers, bb determines white flowers. A population of 300 red individuals, 400 pink individuals and 300 white individuals conducts random cross-pollination. If there is no influence of evolutionary factors, the genotype composition of the population in F1 is

A) 0.25 BB+0.50Bb+0.25bb=1. B) 0.36 BB+0.48Bb+0.16bb=1

C) 0.81 BB+0.18Bb+0.01bb=1. D) 0.49 BB+0.42Bb+0.09bb=1

Solution: - Total number of individuals in the population at P: 300 + 400 + 300 = 1000

Genotype frequency BB = 300 / 1000 = 0.3; Genotype frequency Bb = 400 / 1000 =

0.4

Genotype frequency bb = 300 / 1000 = 0.3 => pA = 0.3 + 0.4 / 2 = 0.5 ; qa = 0.3 + 0.4 / 2

= 0.5

- So the genotype composition of the population in F 1 is: 0.25 BB + 0.50Bb + 0.25bb = 1.

select A

Lesson 4 : Albinism is caused by a recessive gene located on an autosome. In district A, there are 106 people , 100 of whom have albinism. The probability of encountering a normal person with a heterozygous genotype is:

A)1.98. B)0.198. C)0.0198. D)0.00198

Solution: Let a be the recessive gene that causes albinism Genotype aa: person with albinism We have: q 2 aa = 100 / 1000,000 => qa = 1/100 = 0.01

Which: pA + qa = 1 => pA = 1- qa = 1 – 0.01 = 0.99

2pqAa = 2 x 0.01 x 0.99 = 0.0198 choose C

Lesson 5 : Knowing that allele A determines gray fur is completely dominant over allele a that determines white fur, the alleles are located on autosomes. A mouse population in the initial generation has 1020 homozygous gray fur mice, 510 mice with heterozygous genotype. When the population reaches equilibrium, there are 3600 individuals.

Using the above data answer questions a) and b) below:

a) The relative frequency of each allele is:

A. A: a = 1/6 : 5/6 B. A: a = 5/6 : 1/6 C. A: a = 4/6 : 2/6 DA: a = 0.7 : 0.3

b) Number of mice of each genotype when reaching equilibrium:

A. AA = 1000; Aa = 2500; aa = 100 B. AA = 1000; Aa = 100; aa = 2500

C. AA = 2500; Aa = 100; aa = 1000 D. AA = 2500; Aa = 1000; aa

= 100

Solution: a) The relative frequency of each allele is:

Total number of mice in the population in the starting generation: 1020 + 510 = 1530

=> Genotype frequency AA = 1020 / 1530 = 2 / 3 ; Genotype frequency Aa = 510 / 1530 = 1 / 3

So: The genotype composition in the starting generation is 2/3 AA + 1/3 Aa = 1. The relative frequency of each allele is:

pA = 2/3 + ( 1/3 : 2 ) = 5 / 6 ; qa = 0 + ( 1/3 : 2 ) = 1 / 6 choose B

b) Results of random mating between individuals in generation P:

P: (5/6A: 1/6 a) x (5/6A: 1/6 a) = 25AA: 10Aa: 1aa (or pennett grid) So: Number of mice of each genotype when reaching equilibrium:

Genotype AA = ( 25 : 36 ) 3600 = 2500 ; Genotype Aa = ( 10 : 36 ) 3600 = 1000

Genotype aa = (1:36) 3600 = 100 choose D

Lesson 6: A herd of cows has a balanced genotype composition, with the relative frequency of the allele that determines black fur being 0.6, and the relative frequency of the allele that determines yellow fur being 0.4. What is the phenotypic ratio of this herd of cows?

A) 84% black-haired cows, 16% yellow-haired cows. B) 16% black-haired cows, 84% yellow-haired cows. C) 75% black-haired cows, 25% yellow-haired cows. D) 99% black-haired cows, 1% yellow-haired cows. Solution: Frequency of population AA = 0.36 Frequency of population Aa = 2( 0.6 x 0.4 ) = 0.48; Frequency of population aa = 0.16

The phenotypic ratio of black-haired cows is: 0.36 + 0.48 = 0.84 = 84%

Phenotypic ratio of yellow-haired cows: 0.16 = 16% choose A

Lesson 7: A cross-pollinating population has a balanced genotype composition, with red flowers accounting for 84%. What is the genotype composition of the population (B determines red flowers completely dominant over b determines white flowers)?

A)0.16 BB + 0.48 Bb + 0.36 bb = 1. B)0.36 BB + 0.48 Bb + 0.16 bb = 1. C)0.25 BB + 0.50 Bb + 0.25 bb = 1. D)0.64 BB + 0.32 Bb + 0.04 bb = 1.

Solution: Red flower phenotype ratio: 84% => White flower phenotype ratio: 16% = 0.16

Genotype frequency bb = 0.16 => qb = 0.4

According to Hardy-Weinberg's law: pB + qb = 1 => pB = 1- qb= 1 - 0.4 = 0.6 Genotype frequency BB= 0.36; Genotype frequency Bb = 2( 0.6 x 0.4 ) = 0.48

The genotype composition of the population is: 0.36 BB + 0.48 Bb + 0.16 bb = 1. choose D

Lesson 8: The human population has blood type A accounting for 0.2125; blood type B accounting for 0.4725; blood type AB accounting for 0.2250; blood type O accounting for 0.090. What is the relative frequency of each allele?

A)p(I A ) = 0.25; q(I B ) = 0.45; r(i) = 0.30 B)p(I A ) = 0.35; q(I B ) = 0.35; r(i) = 0.30

C)p(I A ) = 0.15; q(I B ) = 0.55; r(i) = 0.30 D)p(I A ) = 0.45; q(I B ) = 0.25; r(i) = 0.30

Solution: Let p (I A ); q(I B ), r(i) be the relative frequencies of alleles I A , I B , I O, respectively.

We have: p + q + r = 1 ( * ) Blood O accounts for 0.090 => r(i) = 0.30 Ratio of blood A: I A I A + I A I O = 0.2125 => p2 + 2 pr = 0.2125

* p 2 + 2 pr + r 2 = ( p + r ) 2 = 0.2125 + 0.090 = 0, 3025 = ( 0.55 ) 2

( p + r ) 2 = ( 0.55 ) 2 => p + r = 0.55 => p = 0.55 – 0.30 = 0.25 From: ( * ) => q = 1 – ( p + r ) = 1 - ( 0.25 + 0.30 ) = 0.45

So: The relative frequency of each allele is: p(I A ) = 0.25; q(I B ) = 0.45; r(i) = 0.30

select A

Lesson 9: Given the genetic structure of a human population regarding blood groups A, B, AB, O:

0.25 I A I A + 0.20 I A I O + 0.09 I B I B + 0.12 I B I O + 0.30 I A I B + 0.04I O I O = 1

The relative frequency of each allele I A , I B , I O is:

A) 0.3 : 0.5 : 0.2 B) 0.5 : 0.2 : 0.3 C) 0.5 : 0.3 : 0.2 D) 0.2 : 0.5 : 0 ,3

Solution: Relative frequency of allele I A : 0.25 + ( 0.2 : 2 ) + ( 0.3 : 2 ) = 0.5 Relative frequency of allele I B : 0.05 + ( 0.12 : 2 ) + ( 0.3 : 2 ) = 0.5

Relative frequency of allele I O : 1 - ( 0.5 + 0.3 ) = 0.2 choose C

Lesson 10: In Vietnam, the percentage of blood type O is 48.3%, blood type A is 19.4%, blood type B is 27.9%, blood type AB is 4.4%. What is the relative frequency of I A ?

A)0.128. B)0.287. C)0.504. D)0.209.

Solution: Blood type O accounts for 0.483 => r(i) = 0.695

Blood ratio A: I A I A + I A I O = 0.194 => p 2 + 2 pr = 0.194

* p 2 + 2 pr + r 2 = ( p + r ) 2 = 0.194 + 0.483 = 0, 677 = ( 0.823 ) 2

( p + r ) 2 = ( 0.823 ) 2 => p + r = 0.823 => p = 0.823 – 0.695 = 0.128

select A

Lesson 11: About blood groups A, O, B of a human population in genetic equilibrium. Allele frequencies I A = 0.1, I B = 0.7, I o = 0.2. The frequencies of blood groups A, B, AB, O are respectively:

A. 0.3; 0.4; 0.26; 0.04 B. 0.05; 0.7 ; 0.21; 0.04

C. 0.05; 0.77; 0, 14; 0.04 D. 0.05; 0.81; 0.10; 0.04

Solution: Frequency of blood group O: r 2 = ( 0.2) 2 = 0.04

Frequency of blood group A: p 2 + 2pr = ( 0,1) 2 + 2(( 0,1 ) x ( 0,2 )) = 0,05 Frequency of blood group B: q 2 + 2qr = ( 0,7 ) 2 + 2(( 0,7 ) x ( 0,2 )) = 0,77 Frequency of blood group AB: 2pq = 2(( 0,1 ) x ( 0,7 )) = 0,14 choose C

Lesson 12: A population has 4 genes I, II, III. IV; the number of alleles of each gene is respectively: 2, 3, 4, 5. The number of genotypes obtained in the above random mating population is:

A. 2700 B. 370 C. 120

D. 81

Solution: Gene I has: ((2(2+1) : 2 ) 1 = 3 genotypes; Gene II has: ((3(3+1) : 2 ) 1 = 6 genotypes; Gene III has: ((4(4+1) : 2 ) 1 = 10 genotypes; Gene IV has: ((5(5+1) : 2 ) 1 = 15 genotypes

The total number of genotypes obtained in a random mating population is: 3 x 6 x 10 x 15 = 2700

Select A

Lesson 13: A population has the following structure P: 17.34%AA: 59.32%Aa: 23.34%aa. In the above population, after 3 generations of random mating, which of the following results does not appear in F 3 ?

A. Genotype ratio 22.09%AA : 49.82%Aa : 28.09%aa .

B. Relative frequency of A/a = 0.47/0.53 .

C. The rate of heterozygotes decreases and the rate of homozygotes increases compared to P.

D. The frequency of allele A decreases and the frequency of allele a increases compared to P.

Solution: We have: P: 17.34%AA: 59.32%Aa: 23.34%aa.

Frequency of allele A: ( pA) = 0.1734 + ( 0.5932 : 2 ) = 0.47 Frequency of allele a ( qa ) = 0.2334 + ( 0.5932 : 2 ) = 0.53

Through 1 generation of random mating: ( 0.47) 2 AA : 2 x ( 0.47) x ( 0.53 ) : ( 0.53 ) 2 aa

Genotype ratio 22.09%AA : 49.82%Aa : 28.09%aa. After 3 generations of random mating (F 3 ) the genotype ratio is still 22.09%AA : 49.82%Aa :

28.09%aa.

Thus: answers A, B, C are all correct the frequency of allele A decreases and the frequency of allele a increases compared to P

not appear in F 3 . Select D

Lesson 14: In humans, the gene that determines eye color has 2 alleles (A, a), the gene that determines hair type has 2 alleles (B,

b) The gene that determines blood type has 3 alleles (I A . I B , I O). The genes are located on different chromosomes. The number of different genotypes that can be created from the above 3 genes in the human population is: A.54 B.24 C.10 D.64

Solution: The gene that determines eye color has: (2 (2+1) : 2) 1 = 3 genotypes; the gene that determines hair type has: (2 (2+1) : 2) 1 = 3 genotypes; the gene that determines blood type has: (3 (3+1) : 2) 1 = 6 genotypes.

The number of different genotypes in a human population is: 3 x 3 x 6 = 54 Choose A Exercise 15: In an animal population, consider a gene with 3 alleles located on the autosome and a gene with 2 alleles located on the sex chromosome with no corresponding allele on the Y. This population has the maximum number of genotypes for the above 2 genes: A.30 B.60 C. 18

D.32

Solution: 1 gene has 3 alleles located on an autosome: (3(3+1) : 2 ) 1 = 6 types of genotypes.

1 gene has 2 alleles located on the sex chromosome with no corresponding allele on the Y: there are 5 types of genotypes

- The number of genotypes on Y is 2: X A Y, X a Y

- The number of genotypes on X is 3: X A X A , X a X a , X A X a

So: This population has the maximum number of genotypes for the above 2 genes: 6 x 5 = 30 Choose A

Lesson 16: In humans, gene A determines normal color vision, allele a determines red-green color blindness; gene B determines normal blood clotting, allele b determines hemophilia. These genes are located on the X sex chromosome and have no corresponding allele on the Y. Gene D determines right-handedness, allele d determines left-handedness and is located on the autosome. The maximum number of genotypes for the above 3 loci in the human population is:

A.42 B.36 C.39 D.27

Solution: The genes (AaBb) located on the X sex chromosome have no corresponding allele on the Y: there are 14 genotypes.

- The number of genotypes on Y is 4: X A Y, X a Y, X A Y, X a Y

B bb B

- The number of genotypes on X is 10: X A X A , X a X a , X A X a

X A X A , X a

X a , X A

BBBB

X

a

b,

BB, B b B bb

X A X A , X a

X a , X A X a

X A X a

bbbb B b, b B

Genes located on autosomes (D and d) have: (2(2+1) : 2 ) 1 = 3 genotypes

So: The human population has the maximum number of genotypes for the above 3 loci: 14 x 3 = 42 Choose A

Lesson 17: An initial population has the genetic structure: 0.7AA + 0.3Aa. After one generation of random mating, 4000 individuals are obtained in the offspring. Theoretically, the number of individuals with heterozygous genotypes is

The offspring are: A.90 B.2890 C.1020 D.7680

Solution: P. 0.7AA + 0.3Aa => pA = 0.7 + (0.3 / 2 ) = 0.85 ; qa = 0 + (0.3 / 2 ) = 0.15 F 1 .( 0.85 ) 2 AA + ( 2 x 0.85 x 0.15 ) Aa + ( 0.15 ) 2 aa = 1

F 1 . 0.7225 AA + 0.255 Aa + 0.0225 aa = 1.

So: The number of individuals with heterozygous genotype in the offspring (F1 ) is: 0.255 x 4000 = 1020 Choose C Exercise 18: Suppose a population in genetic equilibrium has 10,000 individuals, of which 100 individuals have homozygous recessive genotype (aa), then the number of individuals with heterozygous genotype (Aa) in the population will be:

A. 9900 B. 900 C. 8100 D. 1800

Solution: We have: q 2 aa = 100 / 10000 = 0.01 => qa = 0.1

The population is in genetic equilibrium => pA = 1 - 0.1 = 0.9 ; 2pqAa = 2 x 0.1 x 0.9 = 0.18

So: The number of individuals with heterozygous genotype (Aa) is: 0.18 x 10000 = 1800 Choose D

Lesson 19: In chickens, A determines black feathers incompletely dominant over a determines white feathers, genotype Aa determines spotted feathers. A population of jungle fowl in genetic equilibrium has 10,000 individuals, of which 4,800 are spotted feathers, the number of black feathers and white feathers in the population are respectively

A.3600, 1600. B.400, 4800. C.900, 4300.

D.4900, 300.

Solution: Genotype ratio of spotted chicken (Aa) = 4800 / 10000 = 0.48

Let p: frequency of allele A (black fur), q: frequency of allele a (white fur)

The jungle fowl population is in genetic equilibrium, according to the Hardy-Weinberg law: ( p + q ) = 1 and 2pq = 0.48 p + q = 1 (1) and pq = 0.24 (2)

According to Viet's law (1), (2) we have the equation: X 2 - X + 0.24 = 0. Solving we get: x 1 = 0.6; x 2 = 0.4 ( x 1 is p; x 2 is q ).

Therefore: Genotype frequency AA (black fur): (0.6) 2 = 0.36 Genotype frequency aa (white fur): (0.4) 2 = 0.16

So: Number of black feathered chickens: 0.36 x 10000 = 3600

Number of white feathered chickens: 0.16 x 10000 = 1600 Choose A

Lesson 20: A mating population is in genetic equilibrium. Considering a gene with 2 alleles (A and a), we see that the number of homozygous dominant individuals is 9 times greater than the number of homozygous recessive individuals. The percentage of heterozygous individuals in this population is:

A.37.5 % B.18.75 % C.3.75 % D.56.25 %

Solution : Let p 2 be the frequency of homozygous dominant genotype, q 2 be the frequency of homozygous recessive genotype.

We have: p 2 = 9 q 2 or p = 3q

Population in genetic equilibrium: p + q = 1

So: 3q + q = 1 => q = 1 / 4 = 0.25 and p = 3 x 0.25 = 0.75

So: The percentage of heterozygous individuals in this population is: 2pq = 2 x 0.25 x 0.75 = 0.375 = 37.5 % Choose A

Lesson 21: In a balanced population, consider 2 pairs of alleles AaBb on 2 different pairs of homologous chromosomes. Allele A has a relative frequency of 0.4 and Allele B has a relative frequency of 0.6. The frequency of each type of gamete in this population is:

A. AB = 0.24

Ab = 0.36

aB = 0.16

ab = 0.24

B. AB = 0.24

Ab = 0.16

aB = 0.36

ab = 0.24

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Lesson plan for developing students capacity in Biology 12-14

Ab = 0.32

aB = 0.36

ab = 0.48

D. AB = 0.48

Ab = 0.16

aB = 0.36

ab = 0.48

C. AB = 0.48

Solution : The population is in genetic equilibrium: p + q = 1

-Allele A: pA = 0.4 => qa = 0.6.

-Allele B: pB = 0.6 => qb = 0.4

So: The frequency of each type of gamete in this population is:

AB = pA x pB = 0.4 x 0.6 = 0.24; Ab = pA x qb = 0.4 x 0.4 = 0.16

aB = qa x pB = 0.6 x 0.6 = 0.36; ab = qa x qb = 0.6 x 0.4 = 0.24 Choose B

Lesson 22: In cats, coat color is determined by the gene located on the X sex chromosome. Red coat color is determined by allele d, black coat: D, heterozygous female cats: Dd have tricolor coat color. When examining 691 cats, the frequency of allele D was determined to be: 89.3%; allele d: 10.7%; the number of tricolor cats counted was 64. Knowing that: determining allele frequency follows the Hardy-Weinberg law. The number of male and female cats with different coat colors in order is:

A.335, 356 B.356, 335 C. 271, 356 D.356,

271

Solution : We have: ( 0.893 ) 2 DD + 2 ( 0.893 x 0.107 ) Dd + ( 0.107 ) 2 dd = 1

2 ( 0.893 x 0.107 ) Dd = 64 => Dd = 64 / 0.191102 = 335 children

Therefore: Number of male cats: 691 – 335 = 356 cats,

Number of female cats with different fur colors: 335 – 64 = 271 cats Choose D

Lesson 23: A population at the time of statistics has the ratio of genotypes as 0.7AA: 0.3aa. Let the population mate randomly for 4 generations, then let it self-mating continuously for 3 generations. What is the ratio of heterozygous individuals in the population? Knowing that there is no mutation, no gene migration, the individuals have the same vitality and fertility:

A. 0.0525 B.0.60 C.0.06 D.0.40

Solution: pA = 0.7; qa = 0.3. Genetic diversity of the population after 4 generations of random mating: 0.49AA; 0.42Aa: 0.09aa

Self-breeding through 3 generations: Aa = (1/2 ) 3 x 0.42 = 0.0525 Choose A

Lesson 24: In humans, A determines black eyes, a: blue eyes, B: curly hair, b: straight hair; related to ABO blood type, there are 4 phenotypes:

- Blood type A is determined by gene I A.

- Blood type B is determined by gene I B.

- Blood type AB corresponds to genotype I A I B .

- Blood type O corresponds to genotype ii.

Knowing that I A and I B are completely dominant over i, the gene pairs that determine the above traits are located on different pairs of autosomes. The number of different possible genotypes (for the above traits) is: A. 32 B. 54 C. 16

D. 24

Prize :

- The gene that determines blood type has 3 alleles: I A , I B , I 0 => Number of genotypes: (3(3+1) : 2) 1 = 6 genotypes

- The gene that determines eye color has 2 alleles: A, a => Number of genotypes: (2(2+1) : 2 ) 1 = 3 genotypes

- The gene that determines hair type has 2 alleles: B, b => Number of genotypes: (2(2+1) : 2 ) 1 = 3 genotypes So: Number of different possible genotypes (for the above traits): 6 x 3 x 3 = 54

Choose B


Chapter IV- GENETIC APPLICATIONS


Lesson 21 - Lesson 18: SELECTING LIVESTOCK AND PLANT BREEDS BASED ON SOURCES OF COMBINATIONAL VARIATIONS


I. Objective:

After completing this lesson, students will be able to:

1. Knowledge

- Explain the mechanism of emergence and the role of combinatorial variation in the process of creating pure lines.

- State the concept of hybrid vigor and present methods of creating hybrids for hybrid vigor.

- Explain why hybrid advantage is usually highest in F1 and gradually decreases in the next generation.

2. Skills

- Develop analytical skills on visual channels, comparison, analysis, generalization and synthesis skills

- Ability to work independently with textbooks

- Improve the skills of analyzing phenomena to understand the nature of the event through selecting new varieties from the source of combined variations.

3. Attitude

- Forming faith in science and human intelligence through achievements in breeding by hybridization methods

4. Capacity development

a/ Knowledge capacity:

- Students can determine what the learning objectives of the topic are .

- Practice and develop analytical and generalizing thinking skills.

- Students can ask many questions about the learning topic/ Life skills:

episode

- Ability to demonstrate confidence when presenting ideas in front of groups, teams, and classes.

- Ability to present thoughts/ideas; collaborate; manage time and assume responsibility, in group activities.

- Ability to search and process information.

- Self-management: Be aware of factors that affect you : impact on

learning process such as friends, learning tools, teachers...

- Correctly identify the rights and obligations of learning the subject...

- Team management : Listening and positive feedback , creating

II. TEACHING METHODS AND TECHNIQUES

1. Teaching methods

- Problem posing and solving methods…

open source

set ...

- Group teaching method, verification method

2. Teaching techniques

-Lightning technique, feedback technique in teaching, brainstorming technique.

III. PREPARATION

1. Teacher:

- Study card.

- Side board/ roki paper

2. HS:

- Rokki paper/side board, felt pen.

- Some pictures of achievements in livestock and plant breeding based on combinatorial variation sources and learning about achievements in applying hybrid advantage in agricultural production in Vietnam.

- Review lesson 34,35 SH9

III- Lesson progress:

1. Review: (5')

a. Question:

Exercise 2 page 73 - Textbook

b. Answer - score:

- The ratio of genotypes of QT is: (2 points)

fAA = 120/1200 = 0.1. fAa = 400/1200 = 0.33. faa = 680/1200 = 0.57.

- Relative frequency of allele pA = 0.1 + 0.33/2 = 0.265. (4 points)

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