The Ability of Liver Resection Surgery to Treat Cancer


CONCLUDE


1. The ability of PTNS liver resection to treat liver cancer

Liver resection is a feasible method to treat solitary HCC cases, with liver resection indications, with a size smaller than 15 cm (in case of location in the left lobe), smaller than 5 cm (in case of location in the right lobe), with a resection surface not related to important structures such as the hepatic pedicle, hepatic vein, and vena cava.

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With the above criteria for selecting patients, PTNS can perform simple liver resections such as left lateral segmentectomy, peripheral liver resections (HPT 2, 3, 4, 5, 6), major anatomical liver resections (right, left, central, anterior segmental, posterior segmental...), with a success rate of 95.9%.

2. Safety level of PTNS liver resection

The Ability of Liver Resection Surgery to Treat Cancer

Liver resection was safe with an overall complication rate of 5% and no mortality during hospitalization. The average blood loss during surgery was 100ml. Complications associated with liver resection included: postoperative bleeding (0.77%), bile leakage (0.77%), and ascites (1.54%).

3. The effectiveness of PTNS liver resection in treating liver cancer

The effectiveness of minimally invasive surgery

Minimally invasive laparoscopic liver resection helps patients recover quickly after surgery and leave the hospital early. Patients recover bowel circulation 2.5 days after surgery, move and do personal hygiene 2.6 days after surgery and stay in hospital for an average of 6 days.

Effective treatment of liver cancer

With appropriate disease selection criteria, PTNS liver resection still ensures the principles of liver cancer treatment, bringing patients relatively good post-operative survival results. Specifically: The rate of resection area more than 1 cm from the tumor is 85.8%. The rate of resection area without cancer cells is 98.8%. No cancer


metastasis of trocar or abdominal cavity seeding. PTNS can still perform anatomical liver resections to best comply with the principles of liver cancer treatment: right, left, posterior, anterior segmental, left middle segmental, left lateral segmental, HPT 3, HPT 4, HPT 5. The average disease-free survival time (no recurrence) is 52.63 ± 3.00 months. The disease-free survival rates at 1, 3, 5 years are 79.3%, 56.0% and 46.8%, respectively. The average overall survival time is 69.43 ± 2.97 months. The overall survival rates at 1, 3, 5 years are 96.4%, 78.7% and 77.3%, respectively.


PROPOSAL


Continue to study and evaluate the role of PTNS liver resection in treating liver cancer.

A better designed comparative study with long-term follow-up of PTNS and open liver resection is needed to further evaluate the role of minimally invasive surgery in the treatment of HCC.

Clinical application

Through research, laparoscopic liver resection surgery gradually forms a technical process. We realize that with appropriate patient selection criteria, hepatobiliary surgeons with laparoscopic skills can safely perform simple liver resections such as left lobe liver resection, peripheral liver HPT resection.

It is important to note the risk of major vascular injury causing severe blood loss for HPT 5 tumors in the early stages of the procedure. Early conversion to open surgery is recommended in cases with severe blood loss prognosis to avoid laparotomy in emergency situations. The extracapsular Glisson pedicle control technique simplifies laparoscopic liver resection, allowing for anatomical segmental resection, reducing blood loss and better compliance with cancer treatment principles.

Major and difficult liver resections need to continue to improve their techniques to increase feasibility and make them easier to apply in the practice of treating liver cancer.

Once evaluated and its effectiveness is confirmed, PTNS liver resection can be technically transferred for application at treatment facilities, bringing patients with liver cancer many benefits of minimally invasive surgery.

LIST OF RELATED RESEARCH WORKS


1. Tran Cong Duy Long, Nguyen Hoang Bac, Nguyen Duc Thuan, Le Tien Dat, Dang Quoc Viet, Pham Hong Phu, Tran Thai Ngoc Huy (2015). "Early results of laparoscopic liver resection for hepatocellular carcinoma". Ho Chi Minh City Medicine . Volume 19, Supplement No. 1, pp. 225 - 233.

2. Tran Cong Duy Long, Nguyen Hoang Bac, Nguyen Duc Thuan, Le Tien Dat, Dang Quoc Viet, Pham Hong Phu, Tran Thai Ngoc Huy (2015). "Mid-term and long-term results after laparoscopic liver resection for hepatocellular carcinoma." Ho Chi Minh City Medicine . Volume 19, Supplement No. 1, pp. 234 - 240.

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