Study on muscle loss in patients with type 2 diabetes and initial evaluation of the effectiveness of exercise intervention - 7


Ischemic changes on ECG are associated with cardiovascular risk and morbidity and mortality [121].

Risk of hypoglycemia

Hypoglycemia is a risk when exercising in patients with type 2 diabetes who use

insulin and insulin secretagogues. In these individuals, if pre-exercise blood glucose is < 5.5 mmol/l, approximately 15-30 g of carbohydrate should be consumed before exercise [122].

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Risk of hyperglycemia

People with type 2 diabetes usually do not need to delay exercise because

Study on muscle loss in patients with type 2 diabetes and initial evaluation of the effectiveness of exercise intervention - 7

high blood sugar, provided you feel well. If

capillary glucose concentration > 16.7 mmol/l, it is important to ensure

Avoid dehydration and monitor for signs and symptoms (e.g., increased thirst, nausea, severe fatigue, blurred vision, or headache), especially during hot and strenuous exercise [122].

Risk of heat-related illness

People with type 2 diabetes may be at higher risk for

those

adverse effects from

hotter environment than normal people

In these patients, metabolic, cardiovascular and neurological disorders reduce the body's ability to detect and dissipate heat.

Therefore, exercise should be performed in a cool, air-conditioned environment [123].

Exercises applied in the study:

This is an exercise recommended by Harvard School issued in 2007 and updated in 2019. The exercise includes 10 relatively simple movements, easy to practice at home and has a low risk of injury. Includes movements for the arm, upper body, abdomen, back, thigh and leg muscles and movements


balance, exercise time is 30 - 45 minutes. Patients can use 500 ml Lavie water bottle instead of dumbbells (see table of contents).


Chapter 2

RESEARCH OBJECTS AND METHODS

2.1. Research subjects

Our study subjects included patients over 60 years old who came for outpatient examination and treatment at Xanh Pon General Hospital, met the selection criteria for the study and were divided into two groups.

Disease group: includes 201 patients diagnosed and treated for type 2

Mobile

Non-diabetic group: included 201 people without type 2 diabetes, similar in gender, age, and BMI.

2.1.1. Criteria for selecting a group of subjects


Are normal people of similar gender and age

compared to small

sick


No diabetes, blood glucose test mmol/l (done 2 different times).

Morning pulse < 5.6

Do not use drugs that affect bone health: corticosteroids, hormones

alternative, non-treatment osteoporosis drugs, calcium drugs, drugs related

blood clotting and vitamin K, history of polyarthritis.


No previous period of bedridden.

Agree to participate in the study.


2.1.2. Criteria for selecting diabetes group


As patients diagnosed with type 2 diabetes according to ADA criteria

2014 was adjusted

knowledge

outpatient at Xanh Pon General Hospital.

person must meet at least one of the following criteria:


Blood glucose

any > 11.1 mmol/l cream

according to

crab symptom

hyperglycemia is acceptable.

(thirst, frequent urination, overeating, unexplained weight loss)

Blood glucose

future

fasting (8-14 hours fasting) > 7.0 mmol/l


Plasma glucose 2 hours after drinking 75g glucose > 11.1 mmol/l


HbA1C (quantitatively determined by chromatography) > 6.5%.

+ For patients being treated for diabetes, the above diagnostic criteria

no more

be

rely on

mining

patient's medical history

time of disease detection, medications used and currently used, and review medical records

patient's medical record

Patient consent to participate in the study


2.1.3. Exclusion criteria


The patient has acute complications of diabetes such as ketosis, increased osmotic pressure, and infection.

acidosis

Bone diseases, dry: bone segment resection, bone foreign body, has been

diagnostics

chemical

dry

heavy,

rheumatoid arthritis,

has been diagnosed

osteoporosis, scoliosis,...


Use the

drugs affect

musculoskeletal: corticosteroids, hormone replacement

anticonvulsant, anticonvulsant

mental,

drug

bone type,

vitamin K, anticoagulant...


Suffering from cancer or bone metastasis, bedridden for > 1 month or more, having had a section of the stomach, intestines, ovaries and uterus removed, or having had a stroke.

Endocrine diseases and some diseases that cause glucose metabolism disorders:

Basedow's disease, hypothyroidism, Cushing's syndrome, hypopituitarism, acromegaly,


nephrotic syndrome, chronic kidney failure, complications of diabetes: ulcers, inflammation, thrombosis, limbs...

The female patient was found to have ovarian tumors, uterine fibroids, and polycystic ovaries.

The patient did not consent to participate in the study.

2.2. Research method

2.2.1. Research design


Objective 1,2: Cross-sectional description, comparison between disease group and control group

non-diabetic and non-diabetic groups compared with disease groups.


Objective 3: Intervention study comparing before and after with time

follow-up is 12 months.

2.2.2. Time and place of research


The study was conducted from April 2016 to December 2016.

2018 at the Examination Department, Rehabilitation Department of Xanh Pon.

2.2.3. Sample size

Goal 1, 2

General Hospital


Calculate the sample size of the diabetic or non-diabetic group using the formula (sample size calculation for estimating proportions).

In there

n: minimum sample size required


α: choose the significance level α= 0.05→ Z(1α/2) = 1.96


d: absolute error (d= 0.05)

p: choose p = 0.16 (Based on the rate of muscle loss in the type 2 diabetes population in

Korea 15.7%) [87].


The minimum sample size for each group was 181 patients. In fact

The diabetic group selected 201 patients, the non-diabetic group selected 203 patients.


Goal 3

Of the 201 patients studied, we selected 98 patients with pre-muscle wasting, muscle wasting and severe muscle wasting. All patients, after being explained about the purpose and effectiveness of resistance training, agreed to participate in the study in objective 2. However, after 12 months, we only collected complete data of 56 patients for analysis.

How to collect data

The patient parameters to be surveyed were recorded in a medical record form specially designed for this study (see appendix).

Design of medical records for each group of diabetes and non-diabetes, tests

Clinical and paraclinical tests are performed separately.

HbA1C test and MTHFR C677 gene mutation test are only present in diabetic patients.

2.2.4. Research variables

2.2.4.1. Clinical:

be done


General information: year of birth, gender, address, occupation, weight, marital status, nutritional status.

Ask about the disease:

career, afternoon


Personal history (diabetes, hypertension, lipid disorders,

money

obstetric history for women) and family history.

Time of illness.


Clinical examination


Measure

height: standard

Made in Japan measuring device located at the Examination Department

Green Pon General Hospital. Straight line patient, must have 3 points

pre

contact with injury

Measure the heel, buttocks and head.


Weight measurement : patient in loose clothing , no shoes

deṕ

and use

Health scale located at the Examination Department of Xanh Pon General Hospital.

BMI (body mass index): calculated by the formula


BMI = Weight (kg)/ Height

height (m)2


Waist circumference : measure the circumference of the abdomen with a non-elastic measuring tape. Take the measurement .

smallest abdominal circumference from iliac crest to navel, patient breathing lightly,

not ventilated. Each patient measured waist circumference twice, the results were averaged.

sum of 2 measurements.


Blood pressure measurement : all patients were measured with the ALPK2 blood pressure monitor .

Made in Japan. Measure blood pressure in a resting state for at least 10 minutes.

minutes, no prior exertion.


Khaḿ

comprehensive clinical

scope and technique: conducted at the Faculty

Medical examination at Xanh Pon General Hospital by graduate students.

2.2.4.2. Testing

Fasting blood glucose (venous blood ) : blood sample is taken when the patient has fasted for 8-14 hours. Quantification is performed by enzyme colorimetric method on Olympus AU 400 biochemical machine .


HbA1C: percentage of glycosylated hemoglobin, normal value of

HbA1C from 4 6%. HbA1c index is done by immunoassay

measure

chisel, use

biochemical machine

Olympus AU 400 at Department of Biochemistry

Xanh Pon General Hospital.


Blood lipids

(CT, TG, HDL C, LDLC):

fasting venipuncture

Blood was centrifuged, fresh serum was separated and quantified immediately. Quantification of CT, TG, HDL C, LDLC components was performed by the method

enzyme colorimeter, using the biochemical machine of Xanh Pon General Hospital.

Olympus AU 400 at Department of Biochemistry

MTHFR C677T gene polymorphism testing: (see appendix)

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