Jaundice: Often Severe With Typical Symptoms


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- Starts with symptoms of high fever, chills, headache, vomiting, abdominal pain and diarrhea


- Congestion, hemorrhage: red skin, red eyes, sometimes bleeding under the membrane

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nosebleeds, subcutaneous bleeding, bloody stools.

- Large, firm, slightly painful peripheral lymph nodes, slightly enlarged liver and spleen

Jaundice: Often Severe With Typical Symptoms

- Muscle pain in calves, thighs, neck, abdomen, back

3.1.3. Full development

- Infection-toxic syndrome: prolonged fever, fluctuating skin temperature (continuous fever for 6-7 days fever decreases for 1-4 days then fever returns for a second time within a few days) accompanied by fever with symptoms of rapid pulse, muffled heart sounds, decreased blood pressure, the patient is lethargic, lethargic, and may be delirious.

- Hepato-renal syndrome: enlarged and painful liver, yellow skin and eye mucosa on a congested background (red-yellow skin), dark yellow urine, pain in the lumbar region, oliguria or anuria.

- Hemorrhagic syndrome

- Muscle pain symptoms

- During this stage, some patients may often have meningitis syndrome.

3.2. Paraclinical

- CBC: decreased red blood cell count, increased white blood cell count and increased neutrophil ratio.

- Urine: contains Albumin, red blood cells, white blood cells, urinary casts

- Blood urea, blood creatinine increased

- Free bilirubin in blood increased.

- Liver enzymes: slightly increased

- Gros, Maclagan (+)

- Petit mactin (+) (from 10-12 days onwards, antibodies last 2-20 years later)

4. Clinical form

4.1. Jaundice : often severe with typical symptoms

4.2. Non-jaundice form

- Simple kidney disease: high fever, chills, nephritis, blood urea test shows increased.

- Simple meningitis: high fever, headache, vomiting, lumbar puncture: increased pressure, increased protein (< 1g/l), increased cells mainly lymphocytes

- Flu-like symptoms: fever, body aches, muscle, bone and joint pain.

5. Diagnosis

5.1. Definitive diagnosis

- Epidemiology

- Clinical

- Paraclinical

5.2. Differential diagnosis

- Sepsis: no muscle pain, primary bacterial foci.

- Primary malaria: no muscle pain, no congestion, bleeding, blood test shows malaria parasites.

- Dengue hemorrhagic: no muscle pain, no hepatorenal syndrome

- Viral hepatitis

6. Complications

- Acute renal failure

- Hemorrhage

- Myocarditis

- Neurological: peripheral nerve palsy upward type

- Eyes: conjunctivitis, uveitis.

7. Treatment

7.1. Specific treatment

- Use Penicillin at a dose of 4-6 million IU /24/hour (intramuscular injection) until fever is gone 2

day.


- For mild cases, there is no need to use parasites (because they will release endotoxins )

serious illness)

7.2. Symptomatic treatment – ​​mechanism

- Replenish water and electrolytes with isochronic saline solution 1-1.5 liters/24/hour

- Diuretic: Hypothiazide 0.25g: 1-2 tablets/24 hours

- Heart support with uabain

- If bleeding is severe: blood transfusion, vitamin K

- If anuria or high blood urea: peritoneal dialysis or hemodialysis

create.

7.3. Care – nutrition

- Patients rest in bed, monitor pulse, temperature, blood pressure, maintain personal hygiene, prevent ulcers and secondary infections.

- Give liquid food, foods rich in protein and vitamins until the patient's fever subsides, then return to normal diet. If blood urea is high, reduce protein in the diet.

8. Disease prevention

- Eradicating natural outbreaks is a difficult task, so we can only limit contact with water and mud in outbreaks, and keep food clean to avoid contamination.

- People who clean sewers need protective gloves and boots.

- Vaccination


VALUATION

1. Describe the epidemiological characteristics and preventive measures for leptospirosis causing jaundice and bleeding?

2. Describe the clinical symptoms of jaundice and bleeding?

3. Fill in the blanks in the following sentences.

Question 1. What are the diagnostic bases for jaundice and bleeding?

A.................

B.................

C.................

Question 2. Hemorrhagic jaundice should be differentiated from the following diseases: A..................

B.................

C.................

D...................

Question 3. Complications of leptospirosis include jaundice and bleeding.

A.................

B.................

C.................

D. Nerves, eyes

Question 4. Measures to prevent leptospirosis, jaundice, and bleeding.

A. Elimination of natural epidemics. B.................

C.................

D.................

Lesson 37

rabies


TARGET

1. Describe the causes and epidemiological characteristics of rabies.

2. Describe the clinical symptoms of rabies in humans.

3. Describe measures to diagnose and prevent rabies.


CONTENT

1. General

It is an extremely dangerous infectious disease transmitted from animals to humans caused by the rabies virus. Up to now, when a patient has a rabies attack, the mortality rate is 100%.

2. Causes – epidemiology

2.1. Cause : caused by rabies virus

- Rabies virus is 100 - 150Nm in size, living as a parasite in the nerve cells of the central nervous system of humans or animals.

- Resistance of rabies virus: poor resistance, easy to die in the outside environment.

2.2. Epidemiology

2.2.1. Source of disease : rabies is basically a disease of warm-blooded animals (dogs, cats, buffalo, cows, civets, squirrels, etc.). The disease is transmitted to humans mainly by dogs and sometimes by cats.

* Rabies in dogs:

+ Incubation period: several weeks to several months

+ Full development: manifests in one of two states

- Aggressive state: dogs show signs of excitement, behavioral changes, fever, open mouth to breathe, run away from home, bite and tear around, drink a lot of water and chew on unusual objects, then have breathing disorders and die.

- Paralysis: starts with paralysis of the hind limbs and gradually spreads to the front limbs, drooling, breathing disorders and death.

- From the time of rabies to death is 2-7 days, rarely no case.

die.

2.2.2. Transmission route

- Through the skin and mucous membranes, mainly due to bites infected with viruses in dog saliva.

- Through the skin and mucous membranes: due to skin and mucous membranes being scratched and coming into contact with contaminated objects.

- There is no direct transmission between people, although the rabies virus is present in the saliva of sick people.

2.2.3. Sensitivity – immunity

- Humans and warm-blooded animals are highly susceptible to rabies virus, especially dangerous with deep bites, bites on the head - face - neck.

- Can cause active and passive immunity with vaccines and antiserum

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2.2.4. Translation characteristics

- Occurs year round but more common in hot seasons.

3. Clinical symptoms

3.1. Aggressive form

3.1.1. Incubation period : 15 – 55 days, in rare cases the incubation period can last for years.

3.1.2. Full-blown (rabies attack)

+ Progression: pain or tingling at the bite site, pain along the nerve, mild fever, unexplained fear, insomnia.

+ Special symptoms of rabies (due to damage to the brain stem)

- Mild fever

- Breathing disorder: deep and noisy breathing "like lack of air" intermittent exhalation then pause and then deep breathing sometimes like xenophobic breathing.

- High stimulation: hearing is good, eyes are sharp, skin is sensitive, genitals are stimulated and sometimes cause pain, even mild external stimulation can make the patient startled, panic, and scream.

- Fear of water and wind: is the most important symptom when giving the patient water to drink or even just seeing water causes the laryngeal muscles to spasm causing pain, even a light wind can cause the patient to have difficulty breathing.

- Dilated pupils, rapid pulse, and increased salivation.

- Completely conscious until death.

- From the time of seizure to death is 2-4 days.

3.2. Paralysis

- The patient had severe back pain and paralysis of both lower limbs, accompanied by urinary retention and constipation.

- Symptoms of irritation, fear of water, fear of wind are not clear.

- Paralysis gradually spreads to the upper limbs, neck, face, and tongue.

- From the onset of rabies to death is 6-8 days.

4. Progression and complications

Rabies attacks become increasingly severe with serious disorders: respiratory arrest, cardiac arrest at any time without hope of cure. The current mortality rate when an attack occurs is 100%.

5. Diagnosis

5.1. Definitive diagnosis

- Clinical

- Epidemiology

5.2. Differential diagnosis

- Fear of water, choking on water in pregnant women.

- Delusional rabies due to being bitten by a healthy dog: the patient is afraid of water and wind but can still drink water, has no respiratory disorders, and no central nervous system disorders.

- Paralytic rabies: needs to be differentiated from paralysis due to encephalitis, myelitis, and polyneuritis.

5. Treatment

- Let the patient lie in the isolation room

- Give sedatives.

6. Disease prevention

+ Strengthen the law on dog keeping: dogs must be registered and vaccinated regularly, dogs must not be allowed to run free, dogs on the street must be muzzled.

+ When bitten by a dog:

- At the bite wound: wash the bite wound with concentrated soapy water to stop bleeding, do not squeeze, apply concentrated iodine.

- Take the dog to the vet or lock it up, feed it normally and monitor it for 15 days. During the monitoring period, if the dog dies, runs away or is not monitored, the patient must be advised to get a rabies vaccine immediately.

- If a suspected rabid dog bites the head, face, neck, or has multiple deep bites, the patient must be given anti-rabies serum before vaccination (dose 0.2ml/kg using the Bereska method).

- If the dog is monitored for 15 days without death, the patient should stop vaccination.

- Rabies vaccine.

Fuenzalida: 6 basic injections and 3 booster injections (after 1, 3, 6 months). The vaccine is only effective for 6 months, so if you are bitten by a rabid animal after 6 months, you must start the injection again. During the vaccination process, the patient needs to rest, recuperate, not drink alcohol, avoid cold, and avoid mental stress.

+ Should not be injected in the following cases:

- Dog bites through thick clothes without scratching the skin

- Dog licks healthy skin.

- People who have contact with people with rabies

- People who eat cooked food made from rabid animals

- The man had gone mad.


VALUATION

1. Describe the epidemiological characteristics of rabies?

2. Describe measures to prevent rabies?

3. Fill in the blanks in the following sentences.

Question 1. Clinical symptoms of rabies A.................

B.................

C.................

D...................

E. Dilated pupils, rapid pulse, profuse salivation, and mental alertness until death.

Question 2. Diagnosis of rabies.

A.................

B.................

Question 3. Rabies needs to be distinguished from the following diseases:

A. Fear of water, choking on water in pregnant women. B.................

C.................

Question 4. Rabies vaccination should not be given in the following cases:

A. The dog bit through thick clothes and did not scratch the skin. B..................

C.................

D. People who eat cooked food made from rabid animals E ...............

Lesson 38

HIV-AIDS


TARGET

1. Describe the cause, definition and transmission method of AIDS.

2. Describe the main clinical pictures of AIDS.

3. Describe the methods of diagnosis and treatment of AIDS.

4. Describe measures to prevent HIV infection.


CONTENT

1. Definition

Acquired immunodeficiency syndrome is caused by the effects of the Human immunodeficiency virus (HIV), which causes the body to lose resistance to pathogenic microorganisms. These microorganisms, which normally do not cause disease, now become pathogenic, creating opportunistic infections and causing cancer to develop.

2. Causes

HIV under an electron microscope is a molecule with a diameter of 110Nm, has an envelope with a core containing RNA and proteins inside.

When HIV enters the body, it will invade T lymphocytes, mononuclear macrophages and some other cells, then it will develop in these cells.

HIV resistance is very weak.

- Inactivated in Javen water after 1 minute, 70o alcohol after 1 minute.

- Inactivate at 56 o C for 30 minutes, at 100 o C for 1 minute.

3. Transmission route

To date, it has been confirmed that HIV is present in:

- Semen and vaginal mucus

- Blood and blood products

- Saliva, tears, cerebrospinal fluid, urine.

- Breast milk.

3.1. Sexual transmission

- Homosexuality.

- Heterosexuality.

In general, heterosexuality accounts for 71% of the world's population, while homosexuality accounts for 15%.

3.2. Transmission through blood

- Blood transfusion and blood products.

- Through drug injection

- Through medical procedures

3.3. Mother to child transmission

- Through the placenta during fetal life

- During labor

- After birth through breast milk.

4. Clinical symptoms

AIDS is the final stage of a long process of immune system erosion caused by HIV, the vast majority of people infected with HIV today have no symptoms.

AIDS, the rate of progression to AIDS in HIV-infected people ranges from 4-10%/1 year. A large number will have clinical symptoms within 10-15 years after having a (+) serological reaction.

4.1. Acute HIV infection stage (window period)

Within a few days to a few weeks as the virus multiplies, symptoms of acute HIV infection may appear. These symptoms are nonspecific and include fever, abdominal pain, rash, drowsiness, cough, muscle pain, sweating, etc., which can easily be confused with the flu or infectious mononucleosis. HIV antibodies can be detected a few weeks after infection.

4.2. Asymptomatic infection stage

HIV (+) infected people have a clinical asymptomatic period lasting 2-8 years or longer.

4.3. Clinical manifestation stage

4.3.1. Clinical stage 1: persistent generalized lymphadenopathy

- Swollen peripheral lymph nodes (both groin and armpit lymph nodes) diameter > 1cm

- Accompanying symptoms: fever, weight loss, night sweats.

- The patient is still functioning normally.

4.3.2. Clinical stage 2 : early stage (mild)

- Weight loss < 10% of body weight

- Mild skin and mucosal manifestations: seborrheic dermatitis, itching, angular cheilitis, recurrent mouth ulcers.

- Zone within the last 5 years

- Recurrent upper respiratory tract infections.

4.3.3. Clinical stage 3 : Intermediate period

- Weight loss > 100% body weight

- Unexplained persistent diarrhea > 1 month

- Oral candidiasis.

- Severe infections (pneumonia, pyomyositis)

- Tuberculosis in the last year.

4.3.4. Clinical stage 4 : (severe stage – essentially equal to AIDS)

- HIV wasting syndrome

. Weight loss > 10% of body weight

. Unexplained persistent diarrhea or unexplained persistent fatigue and fever

- Herpes simplex virus infection of the skin and mucous membranes > 1 month

- Candida infection of the esophagus, trachea, bronchi or lungs

- Salmonella sepsis (not typhoid)

- Pulmonary tuberculosis, extrapulmonary tuberculosis.

- Kaposi's sarcoma (is a type of vascular endothelial cancer of the skin - mucous membranes, viscera and lymph nodes that begins as purple or brown pigmented patches tumor)

- HIV encephalopathy: cognitive dysfunction or motor dysfunction (progressive over weeks or months without an ongoing illness or condition other than HIV that can explain the condition).

5. Testing

5.1. Finding antibodies to HIV by reactions

- Elisa

- Indirect immunofluorescence

- Nuclear immunoassay

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